Tg(Th-Peo1*,-EGFP)2Gcor
Transgene Detail
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| Nomenclature |
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Symbol:
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Tg(Th-Peo1*,-EGFP)2Gcor
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Name:
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transgene insertion 2, Gino A Cortopassi
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MGI ID: |
MGI:5447072 |
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Transgene:
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Tg(Th-Peo1*,-EGFP)2Gcor
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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Not Specified
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene contains 9.0 kb of upstream sequence from the rat tyrosine hydroxylase gene that drives dopamine neuron-specific expression of the mouse gene with a silent point mutation at position 1077 (c.1077C->G). This mutation forms a restriction enzyme site and allows for the insertion of 39 nucleotides that produces a duplication of amino acids 353 to 365. An IRES-EGFP and polyadenylation sequence follow the altered mouse gene. Four of six lines have higher EGFP expression than wild-type mice. Lines 1, 2, 3 and 4 contain 181, 227, 141, 97, 42 and 6 copies of the transgene, respectively. (J:188914)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:188914
Song L et al.,
"Mutant Twinkle increases dopaminergic neurodegeneration, mtDNA deletions and modulates Parkin expression."
Hum Mol Genet 2012 Dec 1;21(23):5147-58
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All: |
1 reference(s)
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Analysis Tools
