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| Nomenclature |
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Symbol:
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Tg(Neurod2-Smo*A2)#Jols
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Name:
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transgene insertion, James M Olson
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MGI ID: |
MGI:5447065 |
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Synonyms: |
ND2:SmoA2 |
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Transgene:
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Tg(Neurod2-Smo*A2)#Jols
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The ND2:SmoA2 transgene contains the entire mouse smoothened homolog (Drosophila) Smo gene, with the constitutively active point mutation SmoA2 (S537N), driven by the 1kb mouse neurogenic differentiation 2 (Neurod2) promoter. Four lines were generated (221, 222, 225 and 242). All lines exhibit a low level of transgene expression (4-, 1-, 3- and 2-fold, respectively for each line relative to wild-type levels). The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:93861)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:93861
Hallahan AR et al.,
"The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas."
Cancer Res 2004 Nov 1;64(21):7794-800
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All: |
2 reference(s)
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Analysis Tools
