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| Nomenclature |
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Symbol:
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Tg(Prnp-FUS)WT3Cshw
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Name:
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transgene insertion WT3, Christopher Shaw
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MGI ID: |
MGI:5445385 |
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Synonyms: |
hFUS, PrP-hFUS line WT3, PrP-hFUS-WT3 |
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Transgene:
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Tg(Prnp-FUS)WT3Cshw
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x Crl:CD1(ICR))F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene was designed to have the mouse prion protein promoter sequences (from vector MoPrp.Xho) and a human wild-type Fused in sarcoma (FUS) cDNA sequence with N-terminal hemagglutinin-tag (HA-hFUS). Three founders were established, including line WT3. (J:189360)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:189360
Mitchell JC et al.,
"Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashion."
Acta Neuropathol 2012 Sep 9;():
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All: |
1 reference(s)
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Analysis Tools
