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| Nomenclature |
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Symbol:
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Tg(tetO-IL1B)KBry
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Name:
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transgene insertion K, Kristina Bry
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MGI ID: |
MGI:5444502 |
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Synonyms: |
(tetO)7CMV-hIL-1beta |
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Transgene:
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Tg(tetO-IL1B)KBry
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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Not Specified
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene contains the human IL1B cDNA coding for the active, mature protein which was inserted between seven copies of the tetracycline Operator (tetO)7-CMV minimal promoter and the bovine growth factor polyadenylation signals sequence. TetO, when present in cells also carrying a tetracycline transactivator (tTA) or reverse transactivator (rtTA) transgene, is inactivated or activated, respectively, by the administration of tetracycline or its analogue doxycycline. Three lines were made (K,L, and M) with line K showing highest human IL1B levels. (J:107601)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Notes |
Phenotypic Similarity to Human Syndrome: Bronchopulmonary dysplasia (J:130523).
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| References |
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Original: |
J:107601
Lappalainen U et al.,
"Interleukin-1beta causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung."
Am J Respir Cell Mol Biol 2005 Apr;32(4):311-8
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All: |
6 reference(s)
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Analysis Tools
