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| Nomenclature |
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Symbol:
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Tg(LMNA*G608G)HClns
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Name:
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transgene insertion H, Francis Collins
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MGI ID: |
MGI:5441745 |
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Transgene:
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Tg(LMNA*G608G)HClns
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The 164.4 kb human BAC RP11-702H12 containing the entire LMNA gene, as well as the UBQLN4, MAPBPIP, and RAB25 genes was modified to insert the G608G HGPS mutation and a FRT site flanked kanamycin selection cassette into exon 11 of the LMNA gene. The kanamycin selection cassette was removed by transient Flp-recombinase expression. The resulting circular BAC transgene, which contains the G608G mutation in exon 11, and 109 extra nucleotides in intron 10 including an FRT site, EcoRI site, and SacI site, was microinjected into C57BL/6 donor eggs. Founder line H was subsequently established. (J:107176)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:107176
Varga R et al.,
"Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome."
Proc Natl Acad Sci U S A 2006 Feb 28;103(9):3250-5
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All: |
1 reference(s)
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Analysis Tools
