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| Nomenclature |
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Symbol:
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Tg(Igkv3-5*-MYC)#Plbe
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Name:
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transgene insertion, P Leif Bergsagel
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MGI ID: |
MGI:5441311 |
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Synonyms: |
Vk*MYC |
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Transgene:
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Tg(Igkv3-5*-MYC)#Plbe
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The mouse promoter drives B cell-specific expression of the human MYC coding sequence (exons 2 and 3). A codon mutation generates a STOP codon at the third codon (TCG to TAG) and prevents expression of MYC. The codon substitution created a DGYW motif, a known preferential target sequence for somatic hypermutation, that can activate MYC translation following sporadic reversion. Lines 11 and 24 (20 and 8 copies of the transgene, respectively) were generated. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:99667)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:131912
Chesi M et al.,
"AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies."
Cancer Cell 2008 Feb;13(2):167-80
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All: |
4 reference(s)
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Analysis Tools
