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| Nomenclature |
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Symbol:
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Tg(Prnp-HSPB1*R136W)1Kolb
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Name:
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transgene insertion 1, Stephen Kolb
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MGI ID: |
MGI:5440458 |
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Synonyms: |
PrP-HSPB1 (R136W) |
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Transgene:
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Tg(Prnp-HSPB1*R136W)1Kolb
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: Mouse prion protein promoter drives expression of the human HSBP1 open reading frame bearing a C406T nucleotide (R136W amino acid) substitution. Line 1 was generated. (J:188399)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:188399
Srivastava AK et al.,
"Mutant HSPB1 overexpression in neurons is sufficient to cause age-related motor neuronopathy in mice."
Neurobiol Dis 2012 Aug;47(2):163-73
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All: |
1 reference(s)
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Analysis Tools
