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| Nomenclature |
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Symbol:
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b2b227Clo
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Name:
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Mutant line 227;
Bench to Bassinet Program (B2B/CVDC), mutation 227 Cecilia Lo
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MGI ID: |
MGI:5437098 |
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Synonyms: |
Scrappy |
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Gene:
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b2b227Clo
Location:
unknown
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Mutant 227-002-NC exhibits dextrocardia with duplicated inferior vena cava (IVC)
Show the 11 image(s) involving this allele.
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Mutation
origin |
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Strain of Origin:
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C57BL/6J
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Mutation
description |
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Allele
Type: | |
Chemically induced (ENU) |
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Mutation: | |
Undefined |
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Mutation details: This ENU-induced mutation line was isolated in a screen at the University of Pittsburgh. More than one mutation in this line results in a discernible phenotype in a homozygous recessive screen. At least two segregating phenotype groups are identified. See b2b227.1Clo and b2b227.2Clo. (J:175213)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Summative Diagnosis:
Mutant Type 1:
Cardiac phenotype: Congenital heart disease associated with heterotaxy such as double outlet right ventricle (DORV) with subaortic ventricular septal defect (VSD), dextrocardia/mesocardia.
Noncardiac phenotype: dextrogastria, hypoplastic spleen, cystic lung, immotile/slow/dyskinetic cilia
Mutant Type 2: Biventricular hypertrophy
Phenotypic Similarity to Human Syndrome:
Mutant Type 1: Heterotaxy, Kartagener's syndrome, Primary ciliary dyskinesia
Mutant Type 2: Cardiac hypertrophy
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Analysis Tools
