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| Nomenclature |
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Symbol:
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Slc5a1tm1.1Koep
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Name:
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solute carrier family 5 (sodium/glucose cotransporter), member 1;
targeted mutation 1.1, Hermann Koepsell
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MGI ID: |
MGI:5433400 |
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Gene:
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Slc5a1
Location:
Chr5:33104219-33162872 bp, + strand
Genetic Position: Chr5,
17.46 cM, cytoband B1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:186790
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 1 was flanked by a floxed neo cassette and an additional loxP site. Cre-mediated recombination removed the neo cassette and exon 1. Western blot analysis of brush border membrane vesicles confirmed the absence of protein expression. (J:186790)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Slc5a1 Mutation:
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16 strains or lines available |
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| References |
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Original: |
J:186790
Gorboulev V et al.,
"Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion."
Diabetes 2012 Jan;61(1):187-96
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All: |
2 reference(s)
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Analysis Tools
