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| Nomenclature |
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Symbol:
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Tg(tetO-IGF1R)1Ramo
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Name:
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transgene insertion 1, Roger A Moorehead
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MGI ID: |
MGI:5432255 |
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Synonyms: |
TRE-IGF1R1 |
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Transgene:
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Tg(tetO-IGF1R)1Ramo
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The tetracycline response element (TRE or tetO) was used to drive inducible expression of the full-length human IGF1R. In double transgenic mice also expressing the tetracycline transactivating or reverse transactivating element (tTA or rtTA), expression of IGF1R can be regulated by doxycycline administration or removal. Four lines were created. (J:121069)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:121069
Jones RA et al.,
"Transgenic overexpression of IGF-IR disrupts mammary ductal morphogenesis and induces tumor formation."
Oncogene 2007 Mar 8;26(11):1636-44
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All: |
2 reference(s)
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Analysis Tools
