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| Nomenclature |
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Symbol:
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Tg(YAC128)55Hay
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Name:
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transgene insertion 55, Michael Hayden
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MGI ID: |
MGI:5432147 |
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Synonyms: |
HD55, YAC128 |
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Transgene:
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Tg(YAC128)55Hay
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A YAC containing a full-length human huntingtin gene under the control of the endogenous human HDH promoter was modified with a 128 CAG repeat expansion. The resulting construct (YAC128) was used to generate transgenic mice. Founder line 55 integrated the fewer copies of the transgene and had lower levels of protein expression compared to line 53. (J:84453)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:84453
Slow EJ et al.,
"Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease."
Hum Mol Genet 2003 Jul 1;12(13):1555-67
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All: |
10 reference(s)
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Analysis Tools
