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| Nomenclature |
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Symbol:
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Tg(CAG-Cfh*)#Mcp
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Name:
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transgene insertion, Matthew C Pickering
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MGI ID: |
MGI:5432032 |
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Synonyms: |
FHdelta16-20 |
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Transgene:
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Tg(CAG-Cfh*)#Mcp
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(CBA x C57BL/6)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A modified version of the CAGGS promoter drives expression of a mouse Cfh gene with a Cys937Stop mutation resulting in a truncated protein that lacks the terminal five SCR domains. The truncated protein is detected in the plasma at levels comparable to the wild-type protein. The truncated protein retained complement regulatory activity but showed impaired binding to heparin and human umbilical vein endothelial cells in vitro. (J:125860)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:125860
Pickering MC et al.,
"Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains."
J Exp Med 2007 Jun 11;204(6):1249-56
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All: |
2 reference(s)
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Analysis Tools
