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| Nomenclature |
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Symbol:
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Arhgap33tm1.1Wbm
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Name:
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Rho GTPase activating protein 33;
targeted mutation 1.1, Walter Birchmeier
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MGI ID: |
MGI:5431233 |
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Gene:
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Arhgap33
Location:
Chr7:30522226-30534180 bp, - strand
Genetic Position: Chr7,
18.43 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:185948
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 7 - 12 were replaced with a lacZ gene with a nuclear localization signal and a self-excising neo cassette via homologous recombination. Western blot and immunoprecipitation analyses confirmed the absence of protein expression in cortical lysates from homozygous mice. LacZ expression is seen in the nervous system. (J:185948)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Arhgap33 Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:185948
Rosario M et al.,
"Neocortical dendritic complexity is controlled during development by NOMA-GAP-dependent inhibition of Cdc42 and activation of cofilin."
Genes Dev 2012 Aug 1;26(15):1743-57
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All: |
1 reference(s)
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Analysis Tools
