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| Nomenclature |
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Symbol:
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Ak7Tg(tetO-Hmox1)67Sami
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Name:
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adenylate kinase 7;
transgene insertion 67, S Alex Mitsialis
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MGI ID: |
MGI:5431002 |
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Synonyms: |
TH67 |
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Gene:
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Ak7
Location:
Chr12:105705982-105782447 bp, + strand
Genetic Position: Chr12,
55.95 cM, cytoband F1
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, gene disruption) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A transgene containing a tetracycline responsive promoter driving expression of Hmox1 inserted into intron 5 in line 67. A T:A base pair deletion was also detected in exon 4 that results in a frameshift mutation. RT-PCR confirmed the absence of endogenous gene transcript expression. (J:186062)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Phenotypic Similarity to Human Syndrome: Ciliary Dyskinesia, Primary (J:186062)
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| References |
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Original: |
J:186062
Fernandez-Gonzalez A et al.,
"Mutation of murine adenylate kinase 7 underlies a primary ciliary dyskinesia phenotype."
Am J Respir Cell Mol Biol 2009 Mar;40(3):305-13
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All: |
1 reference(s)
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Analysis Tools
