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| Nomenclature |
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Symbol:
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Spg20tm1.1Xen
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Name:
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spastic paraplegia 20, spartin (Troyer syndrome) homolog (human);
targeted mutation 1.1, Taconic Biosciences
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MGI ID: |
MGI:5430946 |
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Gene:
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Spg20
Location:
Chr3:55112108-55137322 bp, + strand
Genetic Position: Chr3,
26.53 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:185987
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Most of exon 2 and all of exons 3 through 5 were replaced with a luciferase reporter and a floxed neo cassette. Cre-mediated recombination removed the neo cassette. Western blot analysis confirmed the absence of protein expression in the brain, spinal cord and testis. (J:185987)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Spg20 Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:185987
Renvoise B et al.,
"Spg20-/- mice reveal multimodal functions for Troyer syndrome protein spartin in lipid droplet maintenance, cytokinesis and BMP signaling."
Hum Mol Genet 2012 Aug 15;21(16):3604-18
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All: |
1 reference(s)
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Analysis Tools
