Dnahc5<b2b1565Clo> Chemically induced Allele Detail MGI Mouse (MGI:5430344)

Dnahc5^b2b1565Clo
Chemically induced Allele Detail

Nomenclature

Symbol:	Dnahc5^b2b1565Clo
Name:	dynein, axonemal, heavy chain 5; Bench to Bassinet Program (B2B/CVDC), mutation 1565 Cecilia Lo
MGI ID:	MGI:5430344
Synonyms:	Dnahc5^c.T13210A, Sleepy
Gene:	Dnahc5 Location: Chr15:28203752-28472045 bp, + strand Genetic Position: Chr15, 10.9 cM

Mutant 1565-004-NA displays situs inversus totalis indicated by dextrocardia and mirror symmetric positioning of all visceral organ situs

Show the 7 image(s) involving this allele.

Mutation
origin

Strain of Origin:

C57BL/6J

Mutation
description

Allele Type:		Chemically induced (ENU)
Mutation:		Single point mutation
		Mutation details

Phenotypes

View phenotypes for all genotypes (concatenated display).

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Dnahc5 Mutation:	10 strains or lines available

Notes

Summative Diagnosis:
Situs inversus totalis
Non-Cardiac Phenotype: Immotile airway cilia

Phenotypic Similarity to Human Syndrome: Kartagener's syndrome

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
0100	Situs inversus totalis

References

Original:	J:175213 Lo C, "Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program" MGI Direct Data Submission (B2B/CvDC) 2011;():
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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