Hprttm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno
Targeted Allele Detail
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| Nomenclature |
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Symbol:
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Hprttm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno
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Name:
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hypoxanthine guanine phosphoribosyl transferase;
targeted mutation 1, Genoway
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MGI ID: |
MGI:5428335 |
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Synonyms: |
PLB1 |
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Gene:
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Hprt
Location:
ChrX:52988137-53021659 bp, + strand
Genetic Position: ChrX,
29.31 cM, cytoband A6
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:180977
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: A construct containing the Camk2a promoter, loxP site, human APP cDNA with the Sweden and London mutations (K670N, M671L and V717I), FRT site, IRES, loxP site, human MAPT cDNA with P301L and R406W mutations, FRT site and neo cassette was inserted into the locus. (J:180977)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:180977
Platt B et al.,
"Abnormal cognition, sleep, EEG and brain metabolism in a novel knock-in Alzheimer mouse, PLB1."
PLoS One 2011;6(11):e27068
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All: |
1 reference(s)
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Analysis Tools
