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| Nomenclature |
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Symbol:
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Gata4tm1Grg
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Name:
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GATA binding protein 4;
targeted mutation 1, Vidu Garg
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MGI ID: |
MGI:5427934 |
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Synonyms: |
Gata4 G295Ski |
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Gene:
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Gata4
Location:
Chr14:63198922-63271692 bp, - strand
Genetic Position: Chr14,
33.24 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:185124
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Single point mutation |
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Mutation details: A G to A mutation was introduced in exon 3 creating a glycine to serine substitution and a floxed neo cassette was inserted downstream of exon 4 via homologous recombination. Immunoblot analysis indicated that protein levels in homozygous mice are similar to wild-type. (J:185124)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:185124
Misra C et al.,
"Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo."
PLoS Genet 2012 May;8(5):e1002690
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All: |
1 reference(s)
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Analysis Tools
