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| Nomenclature |
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Symbol:
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Gsk3atm1.1Tac
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Name:
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glycogen synthase kinase 3 alpha;
targeted mutation 1.1, Taconic
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MGI ID: |
MGI:5427913 |
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Synonyms: |
GSK-3alphaflox |
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Gene:
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Gsk3a
Location:
Chr7:25228258-25237851 bp, - strand
Genetic Position: Chr7,
13.73 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:184975
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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C57BL/6NTac
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP site and FRT flanked neo cassette were inserted upstream of exon 2 and a loxP site was inserted downstream of exon 4 a via homologous recombination. Flp mediated recombination removed the neo cassette leaving exons 2 - 4 floxed. (J:184975)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gsk3a Mutation:
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7 strains or lines available |
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| References |
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Original: |
J:184975
Hurtado DE et al.,
"Selectively Silencing GSK-3 Isoforms Reduces Plaques and Tangles in Mouse Models of Alzheimer's Disease."
J Neurosci 2012 May 23;32(21):7392-402
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All: |
1 reference(s)
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Analysis Tools
