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| Nomenclature |
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Symbol:
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Wnk4tm1Pfi
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Name:
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WNK lysine deficient protein kinase 4;
targeted mutation 1, Pfizer, Ltd
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MGI ID: |
MGI:5427702 |
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Gene:
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Wnk4
Location:
Chr11:101260567-101277409 bp, + strand
Genetic Position: Chr11,
64.51 cM
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Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:184790
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Parent Cell Line:
| Other (see notes) (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A genomic fragment, consisting of 75 bp 5' of exon 1, all of exon 1 and 737 bp 3' of exon 1, was replaced with a neo cassette via homologous recombination. Real time PCR and western blot analyses confirmed the absence of expression in homozygous mice. (J:184790)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Wnk4 Mutation:
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4 strains or lines available |
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Notes |
ES cell line - TG-ES01-01 ESM07
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| References |
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Original: |
J:184790
Castaneda-Bueno M et al.,
"Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process."
Proc Natl Acad Sci U S A 2012 May 15;109(20):7929-34
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All: |
1 reference(s)
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Analysis Tools
