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| Nomenclature |
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Symbol:
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Tg(CAG-DMPK*)1323Coop
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Name:
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transgene insertion 1323, Thomas A Cooper
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MGI ID: |
MGI:5426792 |
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Synonyms: |
EpA960 |
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Transgene:
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Tg(CAG-DMPK*)1323Coop
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene contains a ubiquitously expressed pCAGG CMV enhancer/chicken beta-actin promoter, a floxed concatemer of three SV40 polyadenylation sites, and the human DMPK exon 15 containing 960 copies of interrupted CTG repeats (containing CTCGA after every 20 CTG repeats). The SV40 polyadenylation sites prevent expression of RNA from downstream genomic segments, and their removal by Cre-mediated recombination results in transcription and splicing of DMPK exon 15 into the transgene mRNA. Three lines were made, with the 1323 line showing the highest expression of mRNA from the recombined allele. (J:127391)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:127391
Wang GS et al.,
"Elevation of RNA-binding protein CUGBP1 is an early event in an inducible heart-specific mouse model of myotonic dystrophy."
J Clin Invest 2007 Oct;117(10):2802-11
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All: |
3 reference(s)
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Analysis Tools
