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| Nomenclature |
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Symbol:
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Tg(NPHS2-Trpc6*P111Q)F615Walz
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Name:
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transgene insertion F615, Katherina Walz
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MGI ID: |
MGI:5319638 |
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Synonyms: |
Trpc6-HA P111Q |
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Transgene:
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Tg(NPHS2-Trpc6*P111Q)F615Walz
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6J x CBA/J
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The Trpc6-HA wildtype cDNA sequence was made by modifying a Trpc6 cDNA sequence (encoding a 930 amino acid protein) originally isolated from mouse brain tissue by both repairing an A2615G point mutation (D872G) and also by in-frame addition of an influenza virus hemaglutinin epitope (HA-tag) at the 3' end. The cDNA sequence was placed downstream of a 2.5 kbp fragment from the promoter/enhancer region of the human podocin locus (NPHS2) and upstream from a bovine growth hormone polyA sequence. The C332A nucleotide substitution was introduced to produce the amino acid substitution of glutamine for proline at position 111 (P111Q). Lines F615 and F615 were generated. (J:165112)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:165112
Krall P et al.,
"Podocyte-specific overexpression of wild type or mutant trpc6 in mice is sufficient to cause glomerular disease."
PLoS One 2010;5(9):e12859
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All: |
1 reference(s)
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Analysis Tools
