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| Nomenclature |
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Symbol:
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Tg(NPHS2-Trpc6)F419Walz
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Name:
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transgene insertion F419, Katherina Walz
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MGI ID: |
MGI:5319631 |
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Synonyms: |
Trpc6-HA wt |
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Transgene:
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Tg(NPHS2-Trpc6)F419Walz
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6J x CBA/J
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The Trpc6-HA wildtype cDNA sequence was made by modifying a Trpc6 cDNA sequence (encoding a 930 amino acid protein) originally isolated from mouse brain tissue by both repairing an A2615G point mutation (D872G) and also by in-frame addition of an influenza virus hemaglutinin epitope (HA-tag) at the 3' end. The cDNA sequence was placed downstream of a 2.5 kbp fragment from the promoter/enhancer region of the human podocin locus (NPHS2) and upstream from a bovine growth hormone polyA sequence. Line F419 contains 2-4 copies of the transgene. (J:165112)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:165112
Krall P et al.,
"Podocyte-specific overexpression of wild type or mutant trpc6 in mice is sufficient to cause glomerular disease."
PLoS One 2010;5(9):e12859
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All: |
1 reference(s)
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Analysis Tools
