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| Nomenclature |
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Symbol:
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Rhagtm1Goo
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Name:
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Rhesus blood group-associated A glycoprotein;
targeted mutation 1, Dominique Goossens
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MGI ID: |
MGI:5318589 |
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Gene:
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Rhag
Location:
Chr17:40811126-40840754 bp, + strand
Genetic Position: Chr17,
19.54 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:182122
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Duplication |
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Mutation details: A vector isolated from a targeting vector library described in J:115976 was used to generate this null allele. The vector consisted of an upstream portion of the Hprt gene, a loxP site, a puromycin resistance gene, and a 7.1 kb genomic fragment, including exons 2-5, in which a deletion was created. This vector was used in gap repair targeting where the genomic gap in the vector is repaired by the chromosomal DNA template, creating a duplication on the chromosome. Western blot analysis confirmed the absence of expression in homozygous mice. (J:182122)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Rhag Mutation:
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1 strain or line available |
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| References |
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Original: |
J:182122
Goossens D et al.,
"Generation and characterisation of Rhd and Rhag null mice."
Br J Haematol 2010 Jan;148(1):161-72
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All: |
1 reference(s)
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Analysis Tools
