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| Nomenclature |
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Symbol:
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Pax6tm1.2Xzh
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Name:
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paired box gene 6;
targeted mutation 1.2, Xin Zhang
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MGI ID: |
MGI:5317867 |
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Synonyms: |
Pax6deltaDP |
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Gene:
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Pax6
Location:
Chr2:105668896-105703160 bp, + strand
Genetic Position: Chr2,
55.31 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:182769
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (other) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A loxP site and an Sph I site were inserted upstream of the distal enhancer element and the 450 bp proximal enhancer element was replaced with an FRT flanked neo cassette and a loxP site. Recombinase mediated recombination removed the neo cassette and a 3.1 kb region including the distal and the ectodermal enhancer elements. RT-PCR analysis indicates reduced pancreatic expression in homozygous mice at E15.5. (J:182769)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pax6 Mutation:
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33 strains or lines available |
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| References |
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Original: |
J:182769
Carbe C et al.,
"The functional role of the Meis/Prep-binding elements in Pax6 locus during pancreas and eye development."
Dev Biol 2012 Mar 1;363(1):320-9
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All: |
1 reference(s)
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Analysis Tools
