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| Nomenclature |
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Symbol:
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Lgi1tm1.1Ics
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Name:
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leucine-rich repeat LGI family, member 1;
targeted mutation 1.1, Mouse Clinical Institute
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MGI ID: |
MGI:5317113 |
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Gene:
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Lgi1
Location:
Chr19:38264782-38308939 bp, + strand
Genetic Position: Chr19,
32.9 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:182795
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A loxP site was inserted upstream of exon 6. A floxed neo cassette was inserted downstream of exon 7. Cre-mediated recombination removed the neo cassette and exons 6 and 7. Western blot analysis confirmed the absence of protein expression in the brain and spine. (J:182795)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Lgi1 Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:182795
Chabrol E et al.,
"Electroclinical characterization of epileptic seizures in leucine-rich, glioma-inactivated 1-deficient mice."
Brain 2010 Sep;133(9):2749-62
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All: |
1 reference(s)
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Analysis Tools
