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| Nomenclature |
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Symbol:
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Ror2tm1.1Meg
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Name:
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receptor tyrosine kinase-like orphan receptor 2;
targeted mutation 1.1, Michael E Greenberg
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MGI ID: |
MGI:5315485 |
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Synonyms: |
Ror2f |
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Gene:
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Ror2
Location:
Chr13:53109312-53286124 bp, - strand
Genetic Position: Chr13,
27.68 cM, cytoband B3
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Ror1tm1.1Meg/Ror1tm1.1Meg Ror2tm1.1Meg/Ror2tm1.1Meg Tg(Wnt1-cre)11Rth/0 embryos exhibit sympathetic axon branching defects
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:182150
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A lox2272 site was inserted upstream of exon 3 and an FRT flanked neo cassette and lox2272 site were inserted downstream of exon 4 via homologous recombination. Flp mediated recombination removed the neo cassette. Western blot analysis confirms protein expression in homozygous mice is similar to wild-type levels. (J:182150)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:182150
Ho HY et al.,
"Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis."
Proc Natl Acad Sci U S A 2012 Mar 13;109(11):4044-51
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All: |
1 reference(s)
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Analysis Tools
