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| Nomenclature |
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Symbol:
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Tg(CRYBB1-CRYGC*)#Jfhe
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Name:
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transgene insertion, J Fielding Hejtmancik
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MGI ID: |
MGI:5313507 |
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Synonyms: |
CRYGC5bpd, OGO2 |
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Transgene:
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Tg(CRYBB1-CRYGC*)#Jfhe
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene consists of the chicken betaB1-crystallin promoter followed by the human gammaC-crystallin cDNA with a 5 bp duplication in exon 2 (c.119_123dup), the mouse betaA3/A1-crystallin gene splice site including the last 1055 bp of exon 5, intron 5, and exon 6 and the polyadenylation signal. The 5 bp insertion is predicted to result in an amino acid sequence frameshift that produces a new protein comprised of the first 41 amino acids of CRYGC followed by 62 novel amino acids and a new stop codon. (J:181433)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:181433
Ma Z et al.,
"Overexpression of human gammaC-crystallin 5 bp duplication disrupts lens morphology in transgenic mice."
Invest Ophthalmol Vis Sci 2011 Jul;52(8):5369-75
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All: |
1 reference(s)
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Analysis Tools
