b2b1116Clo Chemically induced Allele Detail MGI Mouse (MGI:5311383)

b2b1116Clo
Chemically induced Allele Detail

Nomenclature

Symbol:	b2b1116Clo
Name:	Mutant line 1116; Bench to Bassinet Program (B2B/CVDC), mutation 1116 Cecilia Lo
MGI ID:	MGI:5311383
Synonyms:	Acorn
Gene:	b2b1116Clo Location: unknown

Mutant 1116-002-LB exhibits situs inversus totalis

Show the 13 image(s) involving this allele.

Mutation
origin

Strain of Origin:

C57BL/6J

Mutation
description

Allele Type:		Chemically induced (ENU)
Mutation:		Not Specified
		This ENU-induced mutation was isolated in a screen at the University of Pittsburgh.

Phenotypes

View phenotypes for all genotypes (concatenated display).

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any b2b1116Clo Mutation:	1 strain or line available

Notes

Summative Diagnosis:
Cardiovascular defects: Heterotaxy with congenital heart disease and situs inversus totalis.
Noncardiac defects: dyskinetic/immotile tracheal airway cilia

Phenotypic Similarity to Human Syndrome: Primary ciliary dyskinesia, Kartagener's syndrome, Heterotaxy

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
0100	Situs inversus totalis
0190	Heterotaxy syndrome
3804	Congenital heart disease
3974	{I,L,L}

References

Original:	J:175213 Lo C, "Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program" MGI Direct Data Submission (B2B/CvDC) 2011;():
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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