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| Nomenclature |
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Symbol:
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Tg(Thy1-TARDBP*)BOddo
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Name:
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transgene insertion B, Salvatore Oddo
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MGI ID: |
MGI:5310969 |
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Synonyms: |
TgTDP-25(B) |
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Transgene:
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Tg(Thy1-TARDBP*)BOddo
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene contains the 25-kDa C-terminal fragment of human TARDBP (encoding the last 199 amino acids) under the control of the Thy1.2 neuron specific regulatory sequence. Transgenic mice exhibit an accumulation of the 25-kDa fragment in the cytosolic fraction. Line B is the high expressing line and real-time PCR indicates 4.71 copies of the transgene in this line. (J:180165)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:180165
Caccamo A et al.,
"Cognitive decline typical of frontotemporal lobar degeneration in transgenic mice expressing the 25-kDa C-terminal fragment of TDP-43."
Am J Pathol 2012 Jan;180(1):293-302
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All: |
1 reference(s)
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Analysis Tools
