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| Nomenclature |
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Symbol:
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Cd8atm2.1(Cd4)Asin
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Name:
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CD8 antigen, alpha chain;
targeted mutation 2.1, Alfred Singer
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MGI ID: |
MGI:5309010 |
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Synonyms: |
4in8, Cd8aCD4 |
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Gene:
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Cd8a
Location:
Chr6:71373427-71379171 bp, + strand
Genetic Position: Chr6,
32.14 cM, cytoband C
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:180236
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 1-4 were replaced with a Cd4 cDNA and a floxed neomycin selection cassette. The selection cassette was subsequently removed by cre excision. (J:180236)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Cd8a Mutation:
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14 strains or lines available |
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| References |
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Original: |
J:180236
Adoro S et al.,
"Coreceptor gene imprinting governs thymocyte lineage fate."
EMBO J 2011;31(2):366-77
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All: |
1 reference(s)
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Analysis Tools
