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| Nomenclature |
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Symbol:
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Pitx2tm1.1Dmm
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Name:
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paired-like homeodomain transcription factor 2;
targeted mutation 1.1, Donna M Martin
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MGI ID: |
MGI:5308807 |
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Synonyms: |
Pitx2Taulacz, Pitx2tlz |
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Gene:
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Pitx2
Location:
Chr3:129199878-129219591 bp, + strand
Genetic Position: Chr3,
57.84 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:181058
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 4 was replaced with a splice acceptor, stop codon, IRES, bovine MAPT fused to lacZ (tau-lacZ) and floxed neo cassette. Cre-mediated recombination removed the neo cassette. Immunofluorescence confirmed the absence of protein expression. (J:181058)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:181058
Skidmore JM et al.,
"A novel TaulacZ allele reveals a requirement for Pitx2 in formation of the mammillothalamic tract."
Genesis 2012 Jan;50(1):67-73
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All: |
2 reference(s)
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Analysis Tools
