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| Nomenclature |
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Symbol:
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Lbrlym3
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Name:
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lamin B receptor;
lymphocyte affected 3
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MGI ID: |
MGI:5308091 |
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Gene:
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Lbr
Location:
Chr1:181815316-181842401 bp, - strand
Genetic Position: Chr1,
84.89 cM
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Mutation
origin |
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Strain of Origin:
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C57BL/6
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Mutation
description |
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Allele
Type: | |
Chemically induced (ENU) |
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Mutation: | |
Single point mutation |
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Mutation details: ENU mutagenesis induced a C to A nucleotide substitution in exon 10 that results in the amino acid substitution of alanine for glutamic acid at position 418 (E418A). (J:180355)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Lbr Mutation:
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15 strains or lines available |
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Notes |
Originally isolated from Mpltm1Wsa mice treated with ENU.
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| References |
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Original: |
J:180355
Verhagen AM et al.,
"Reduced lymphocyte longevity and homeostatic proliferation in lamin B receptor-deficient mice results in profound and progressive lymphopenia."
J Immunol 2012 Jan 1;188(1):122-34
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All: |
1 reference(s)
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Analysis Tools
