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| Nomenclature |
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Symbol:
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Tg(CTSG-NUMA1/RARA)#Skr
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Name:
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transgene insertion, Suzanne Kamel-Reid
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MGI ID: |
MGI:5307058 |
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Synonyms: |
hCG-NuMA-RARalpha TM |
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Transgene:
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Tg(CTSG-NUMA1/RARA)#Skr
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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Not Specified
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene consists of a fusion protein containing the N-terminal globular head domain and long central coiled-coil motif of NUMA1, including the oligomerization domain, and the C-terminus, domains C-F, of RARA, including the ATRA-binding site, RA-dependent DNA-binding site, and retinoid X receptor alpha and nuclear corepressor/coactivator interfaces, under the control of the human cathepsin G promoter. This fusion protein results from a translocation t(11:17)(q13;q21) associated with human cases of acute promyelocytic leukemia. The CTSG promoter drives expression in immature cells of the neutrophil lineage. RT-PCR indicates transgene expression in multiple organs at 4.5 months of age. Two lines were made but no line numbers were specified. (J:88103)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:88103
Sukhai MA et al.,
"Myeloid leukemia with promyelocytic features in transgenic mice expressing hCG-NuMA-RARalpha."
Oncogene 2004 Jan 22;23(3):665-78
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All: |
3 reference(s)
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Analysis Tools
