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| Nomenclature |
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Symbol:
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Trp53tm1.1Dgk
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Name:
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transformation related protein 53;
targeted mutation 1.1, David G Kirsch
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MGI ID: |
MGI:5306612 |
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Synonyms: |
p53FRT |
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Gene:
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Trp53
Location:
Chr11:69580359-69591873 bp, + strand
Genetic Position: Chr11,
42.83 cM, cytoband B2-C
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:180576
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A targeting vector was designed to insert a FRT site upstream of exon 2, and a loxP-flanked neomycin resistance (neo) cassette followed by a second FRT site downstream of exon 6. Cre-mediated recombination removed the neo cassette. (J:180576)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:180576
Lee CL et al.,
"Generation of primary tumors with Flp recombinase in FRT-flanked p53 mice."
Dis Model Mech 2012 May;5(3):397-402
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All: |
2 reference(s)
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Analysis Tools
