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| Nomenclature |
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Symbol:
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Sirt1tm1.2Cxd
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Name:
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sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae);
targeted mutation 1.2, Chu-Xia Deng
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MGI ID: |
MGI:5305225 |
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Synonyms: |
Sirt1flox5-6 |
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Gene:
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Sirt1
Location:
Chr10:63319005-63381704 bp, - strand
Genetic Position: Chr10,
32.57 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:179193
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: Germ line, cre mediated recombination was used to remove the neo cassette leaving exons 5 and 6 flanked by loxP sites. Liver specific deletion of the two floxed exons eliminates protein product in the liver. (J:140089, J:179193)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Sirt1 Mutation:
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43 strains or lines available |
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| References |
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Original: |
J:179193
Wang RH et al.,
"Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition."
Int J Biol Sci 2010;6(7):682-90
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All: |
2 reference(s)
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Analysis Tools
