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| Nomenclature |
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Symbol:
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Tg(RP11-209M4)#Gglo
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Name:
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transgene insertion, Gabriela G Loots
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MGI ID: |
MGI:5304449 |
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Synonyms: |
SOST TG, SOSTwt |
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Transgene:
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Tg(RP11-209M4)#Gglo
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene contains the wild-type human BAC RP11-209M4, which contains SOST and the 3' end of MEOX. Three lines were generated (A, B, and an unnamed line). RT-PCR and quantitative PCR confirmed that all lines express human SOST in the mineralized bone of neonatal and adult mice (skull, rib, and femur) and in the adult kidney. No expression of human MEOX was detected. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:99965)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:99965
Loots GG et al.,
"Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease."
Genome Res 2005 Jul;15(7):928-35
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All: |
2 reference(s)
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Analysis Tools
