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| Nomenclature |
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Symbol:
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Tg(CMV-MYOC*Y437H)#Vcs
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Name:
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transgene insertion, Val C Sheffield
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MGI ID: |
MGI:5302242 |
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Synonyms: |
Tg(CMV-MYOCY437H)/Vcs, Tg-MYOCY437H |
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Transgene:
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Tg(CMV-MYOC*Y437H)#Vcs
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6J x SJL/J
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene expresses human myocilin containing the Y437H mutation under the control of the CMV promoter. Expression of the mutant protein is seen in the iridocorneal angle and sclera but is absent in the retina, similarly to endogenous Myoc expression. Mutant protein accumulates in the endoplasmic reticulum. (J:178254)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:178254
Zode GS et al.,
"Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma."
J Clin Invest 2011 Sep 1;121(9):3542-53
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All: |
1 reference(s)
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Analysis Tools
