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| Nomenclature |
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Symbol:
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Mapttm1(Setdb1)Akba
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Name:
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microtubule-associated protein tau;
targeted mutation 1, Schahram Akbarian
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MGI ID: |
MGI:5298877 |
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Synonyms: |
tauSetdb1 |
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Gene:
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Mapt
Location:
Chr11:104231390-104332090 bp, + strand
Genetic Position: Chr11,
67.79 cM, cytoband E1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:178512
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Parent Cell Line:
| AB2.2 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: The myc-tagged mouse cDNA and a neo cassette were inserted downstream of the start codon in exon 2. Western blot analysis confirmed protein expression in the cerebral cortex, striatum, hippocampus, cerebellum, thalamus, hypothalamus, peri-aqueductal gray, and substantia nigra. (J:178512)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:178512
Jiang Y et al.,
"Setdb1-mediated histone H3K9 hypermethylation in neurons worsens the neurological phenotype of Mecp2-deficient mice."
Neuropharmacology 2011 Jun;60(7-8):1088-97
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All: |
1 reference(s)
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Analysis Tools
