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| Nomenclature |
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Symbol:
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Tg(CAG-cat,-Dcn*)#Debi
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Name:
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transgene insertion, David E Birk
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MGI ID: |
MGI:5298093 |
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Synonyms: |
925delTDcn |
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Transgene:
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Tg(CAG-cat,-Dcn*)#Debi
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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Not Specified
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene consists of the ubiquitous CAG promoter followed by a floxed chloramphenicol acetyltransferase (cat) gene and a mutant murine Dcn cDNA with a single base pair deletion at position 952 (delT) resulting in a frameshift mutation and truncation of the C terminal 33 amino acids. The mutation at position 952 in the mouse gene is comparable to the mutation in position 967 in the human gene seen in patients with congenital stromal corneal dystrophy. Cre mediated recombination results in expression of the mutant mouse cDNA. (J:177392)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:177392
Chen S et al.,
"Pathophysiological mechanisms of autosomal dominant congenital stromal corneal dystrophy C-terminal-truncated decorin results in abnormal matrix assembly and altered expression of small leucine-rich proteoglycans."
Am J Pathol 2011 Nov;179(5):2409-19
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All: |
1 reference(s)
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Analysis Tools
