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| Nomenclature |
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Symbol:
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Tg(Ggt1-Hif1a*)43Log
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Name:
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transgene insertion 43, Lorraine J Gudas
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MGI ID: |
MGI:5298013 |
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Synonyms: |
gamma-HIF1alpha-M3, gamma-HIF1alpha-M3-43 |
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Transgene:
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Tg(Ggt1-Hif1a*)43Log
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The rat promoter drives kidney proximal tubule-specific expression of the human cDNA with three amino acid substitutions (P402A, P564A, and N803A). Four lines were generated (8, 25, 32, and 43) with similar phenotypes. Line 43 exhibits the strongest phenotype. (J:177381)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:177381
Fu L et al.,
"Generation of a Mouse Model of Von Hippel-Lindau Kidney Disease Leading to Renal Cancers by Expression of a Constitutively Active Mutant of HIF1alpha."
Cancer Res 2011 Nov 1;71(21):6848-56
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All: |
1 reference(s)
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Analysis Tools
