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| Nomenclature |
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Symbol:
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Tg(Alb-F8)EBmre
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Name:
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transgene insertion E, Birgit M Reipert
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MGI ID: |
MGI:5297954 |
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Transgene:
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Tg(Alb-F8)EBmre
Location:
unknown
Genetic Position: Chr3,
Syntenic
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Transgene
origin |
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Strain of Origin:
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Not Specified
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The promoter drives liver-specific expression of the human cDNA with a poly A signal derived from the human growth hormone and alpha-fetoprotein enhancer elements. Lines E (one insertion on chromosome 3H3) and G (one insertion on chromosome XA6) were generated. Line E does not elicite an antibody response while line G elicites the highest level of antibody response. Protein expression is detected in various organs but not in the circulation. (J:176909)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:176909
van Helden PM et al.,
"Maintenance and break of immune tolerance against human factor VIII in a new transgenic hemophilic mouse model."
Blood 2011 Sep 29;118(13):3698-707
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All: |
1 reference(s)
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Analysis Tools
