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| Nomenclature |
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Symbol:
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Ikbkaptm1.1Id
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Name:
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inhibitor of kappa light polypeptide enhancer in B cells, kinase complex-associated protein;
targeted mutation 1.1, Ioannis Dragatsis
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MGI ID: |
MGI:5297555 |
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Synonyms: |
Ikbkapdelta20 |
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Gene:
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Ikbkap
Location:
Chr4:56749680-56802331 bp, - strand
Genetic Position: Chr4,
31.66 cM
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Cardiovascular and brain malformations in Ikbkaptm1Id/Ikbkaptm1Id and Ikbkaptm1.1Id/Ikbkaptm1.1Id embryos
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:178070
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Parent Cell Line:
| W9.5/W95 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A loxP site was inserted into intron 19 and a floxed neo-stop cassette was inserted into intron 20 via homologous recombination. Cre mediated recombination removed exon 20 and the neo-stop cassette. RT-PCR analysis confirmed the expression of a stable mRNA lacking exon 20. (J:178070)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ikbkap Mutation:
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8 strains or lines available |
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| References |
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Original: |
J:178070
Dietrich P et al.,
"Deletion of exon 20 of the familial dysautonomia gene ikbkap in mice causes developmental delay, cardiovascular defects, and early embryonic lethality."
PLoS One 2011;6(10):e27015
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All: |
2 reference(s)
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Analysis Tools
