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| Nomenclature |
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Symbol:
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Aqp4tm1.1Geno
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Name:
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aquaporin 4;
targeted mutation 1.1, Genoway
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MGI ID: |
MGI:5297539 |
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Synonyms: |
Aqp4flox |
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Gene:
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Aqp4
Location:
Chr18:15389394-15403684 bp, - strand
Genetic Position: Chr18,
8.74 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:177412
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette and left exons 1 through 3 floxed. (J:177412)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Aqp4 Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:177412
Haj-Yasein NN et al.,
"Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet."
Proc Natl Acad Sci U S A 2011 Oct 25;108(43):17815-20
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All: |
1 reference(s)
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Analysis Tools
