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| Nomenclature |
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Symbol:
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Juptm1.1Shou
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Name:
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junction plakoglobin;
targeted mutation 1.1, Weinian Shou
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MGI ID: |
MGI:5296511 |
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Synonyms: |
Jupf |
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Gene:
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Jup
Location:
Chr11:100368958-100397763 bp, - strand
Genetic Position: Chr11,
63.47 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:177567
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin selection cassette flanked by two loxP sites and a fragment including part of Jup introns 2-6 with a third loxP site inserted into intron 5 was engineered downstream of the neomycin selection cassette. The neomycin cassette was removed by breeding with Tg(EIIa-cre)C5379Lmgd mice, leaving exons 3-5 floxed (J:177567)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:177567
Li D et al.,
"Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy."
Hum Mol Genet 2011 Dec 1;20(23):4582-96
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All: |
2 reference(s)
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Analysis Tools
