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| Nomenclature |
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Symbol:
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Tg(Gata1*V205G)1Mym
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Name:
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transgene insertion 1, Masayuki Yamamoto
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MGI ID: |
MGI:5295641 |
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Synonyms: |
V205G |
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Transgene:
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Tg(Gata1*V205G)1Mym
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x DBA/2)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene consists of the murine Gata1 cDNA with a V205G (GTG to GGG) mutation under the control of the Gata1 genomic locus spanning 3.9 kb 5' of the hematopoietic IE exon to the second exon (GATA-1 HRD) which recapitulates endogenous Gata1 gene expression. The valine 205 to glycine substitution has been shown to reduce Zfpm1 (Fog-1) association. Five lines were made. This line is a high-expressing line. (J:89054)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:89054
Shimizu R et al.,
"Transgenic rescue of GATA-1-deficient mice with GATA-1 lacking a FOG-1 association site phenocopies patients with X-linked thrombocytopenia."
Blood 2004 Apr 1;103(7):2560-7
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All: |
2 reference(s)
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Analysis Tools
