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| Nomenclature |
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Symbol:
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Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pion)Pggd
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Name:
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gene trap ROSA 26, Philippe Soriano;
targeted mutation 1, Paul Greengard
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MGI ID: |
MGI:5294908 |
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Synonyms: |
GSAP-RNAi |
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Gene:
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Gt(ROSA)26Sor
Location:
Chr6:113067428-113077333 bp, - strand
Genetic Position: Chr6,
52.73 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:163997
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Parent Cell Line:
| ART4.12 (ES Cell) |
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Strain of Origin:
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(C57BL/6 x 129S6/SvEvTac)F1
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: The short hairpin RNA (shRNA) against Pion (5'-TCCCGGAACTCCATGATTGACAAATTTCAAGAGAATTTGTCAATCATGGAGTTCCTTTTTA-3') was inserted into the locus via RMCE with Gt(ROSA)26Sortm1(CAG-flpe)Arte. The shRNA sequence is under the regulation of the tetO operator and a codon optimized tet repressor (itetR) under the control of a CAG promoter. (J:163997)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gt(ROSA)26Sor Mutation:
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196 strains or lines available |
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| References |
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Original: |
J:163997
He G et al.,
"Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease."
Nature 2010 Sep 2;467(7311):95-8
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All: |
1 reference(s)
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Analysis Tools
