|
|
| Nomenclature |
|
Symbol:
|
Qpctlm1Ingm
|
|
Name:
|
glutaminyl-peptide cyclotransferase-like;
mutation 1, Ingenium Pharmaceuticals
|
|
MGI ID: |
MGI:5294355 |
|
Synonyms: |
isoQC- |
|
Gene:
|
Qpctl
Location:
Chr7:19140217-19149196 bp, - strand
Genetic Position: Chr7,
9.46 cM, cytoband A2
|
|
Mutation
origin |
|
Strain of Origin:
|
C3HeB/FeJ
|
|
Mutation
description |
|
Allele
Type: | |
Chemically induced (ENU) |
|
Mutation: | |
Single point mutation |
| |
|
Mutation details: ENU induced a T to A nucleotide substitution at nucleotide position 442 leading to the
introduction of a stop codon in the open reading frame terminating the protein at amino acid 144.
(J:100122, J:176575)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Qpctl Mutation:
|
1 strain or line available |
|
| References |
|
Original: |
J:176575
Alexandru A et al.,
"Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated A{beta} Is Induced by Pyroglutamate-A{beta} Formation."
J Neurosci 2011 Sep 7;31(36):12790-12801
|
|
All: |
2 reference(s)
|
|
Analysis Tools
