|
|
| Nomenclature |
|
Symbol:
|
Trib2Tg(Thy1-Trh/APP*)2.1Ingm
|
|
Name:
|
tribbles homolog 2 (Drosophila);
transgene insertion 2.1, Ingenium Pharmaceuticals
|
|
MGI ID: |
MGI:5294354 |
|
Synonyms: |
TBA2.1 |
|
Gene:
|
Trib2
Location:
Chr12:15791727-15816877 bp, - strand
Genetic Position: Chr12,
7.25 cM
|
|
Transgene
origin |
|
Strain of Origin:
|
Not Specified
|
|
Transgene
description |
|
Transgene
Type: | |
Transgenic (random, gene disruption) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: The Thy1 regulatory sequence directs expression of a fusion protein of the pre-pro-peptide of murine thyrotropin releasing hormone and the N terminus of the modified human amyloid beta polypeptide, Abeta(Q3?42). This transgene expresses an N terminally truncated A beta protein that is glutamate to glutamine modified at position 3 and engineered to liberate its product preferentially within the secretory pathway. Multiple copies of the transgene inserted into position 15.5-16.5 Mbp (based on NCBI Build 36 ) on chromosome 12 resulting in deletion of Trib2. Maximal transgene expression was seen between P12 and P28. (J:176575)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Trib2 Mutation:
|
9 strains or lines available |
|
| References |
|
Original: |
J:176575
Alexandru A et al.,
"Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated A{beta} Is Induced by Pyroglutamate-A{beta} Formation."
J Neurosci 2011 Sep 7;31(36):12790-12801
|
|
All: |
2 reference(s)
|
|
Analysis Tools
