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| Nomenclature |
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Symbol:
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Cacna1ctm4Hfm
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Name:
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calcium channel, voltage-dependent, L type, alpha 1C subunit;
targeted mutation 4, Franz Hofmann
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MGI ID: |
MGI:5291981 |
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Synonyms: |
Cav1.2I1624E |
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Gene:
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Cacna1c
Location:
Chr6:118592319-118780324 bp, - strand
Genetic Position: Chr6,
55.86 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:175463
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Nucleotide substitutions |
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Mutation details: A floxed neo cassette was inserted upstream of a modified exon 40 in which nucleotide substitutions (ATC to GAG) results in the amino acid substitution of glutamic acid for isoleucine at position 1624 (I1624E). (J:175463)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Cacna1c Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:175463
Poomvanicha M et al.,
"Facilitation and Ca2+-dependent inactivation are modified by mutation of the Ca(v)1.2 channel IQ motif."
J Biol Chem 2011 Jul 29;286(30):26702-7
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All: |
2 reference(s)
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Analysis Tools
